Cost-Utility Analysis of Treatment Sequences for Moderate-to-Severe Crohn's Disease.

ABSTRACT:

Objectives

The clinical pathway for patients with moderate-to-severe Crohn's disease (CD) typically includes sequential pharmacologic treatment as well as surgery, but positioning of different therapies within these sequences remains challenging. Cost-utility analysis rarely captures these sequences and does not incorporate registry data on long-term effectiveness. In this study, we aim to overcome these limitations.

Methods

We developed an individual state transition model with four health states (active disease, remission, and remission due to surgery and death), five sequential treatment lines, and surgery. Efficacy data from network meta-analyses (NMA) for biologic naive and biologic exposed patients were combined with Dutch registry data to forecast long-term benefit, c

SUBMITTER: Versteegh MM 

PROVIDER: S-EPMC12602672 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature