Clinical relevance of intraoperative blood loss in pancreatic surgery: a systematic review and meta-analysis to reappraise the impact on post operative pancreatic fistula.

ABSTRACT:

Background

Postoperative pancreatic fistula (POPF) is the major complication following pancreatic surgery, significantly impacting patient outcomes. Intraoperative blood loss (IBL) represents a modifiable risk factor for POPF, but its actual clinical relevance is not clearly defined. This study explores the available literature to reappraise the association of IBL and the development of POPF.

Methods

A systematic review and meta-analysis of original studies published between January 2006 and August 2025, reporting IBL in patients undergoing pancreatic resections and its association with POPF were performed. Studies that used the International Study Group on Pancreatic Surgery (ISGPS) or the International Study Group on Pancreatic Fistula Definition (ISGPF) definitions for PO

SUBMITTER: Perri G 

PROVIDER: S-EPMC12602675 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature