The impact of fast vs. slow rubidium-82 infusion profile on precision and accuracy of PET myocardial blood flow perfusion metrics using a 1-tissue compartment model.

ABSTRACT:

Aims

Gould's simplified retention model (GSRM), as implemented in the HeartSee software, demonstrates 10% same-day test-retest precision for PET-CT myocardial perfusion using a 50 or 20 mL/min Rb-82 infusions. HeartSee-GSRM also accurately quantifies resting myocardial blood flow (rMBF) in transmural scar (0.26 mL/min/g), aligning with reference standards. However, the impact for varying infusion rates on precision and accuracy of a 1-tissue compartment model (1-TCM) as implemented within 4DM software remains unclear. We assessed whether varying infusion rates of Rb-82 impacts 1-TCM precision and accuracy.

Methods and results

Ninety-eight volunteers (Normals, Clinicals, and Infarcts), underwent 3D PET-CT stress testing. Three resting scans and two stress scans were performed

SUBMITTER: Koos A 

PROVIDER: S-EPMC12602862 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature