Incidence and Short-Term Prognosis of Acute-On-Chronic Liver Failure Defined by Japanese Criteria: A Single-Center Retrospective Cohort Study From Urban Japan.

ABSTRACT:

Background and aim

Acute-on-chronic liver failure (ACLF) carries high short-term mortality, but real-world evidence under the Japanese ACLF criteria remains limited. We assessed incidence, clinical profile, outcomes, and prognostic factors at a tertiary center in urban Japan.

Methods

We retrospectively reviewed 363 consecutive hospitalizations of patients with cirrhosis (2014-2022) at a tertiary care center in Japan. ACLF per Japanese criteria was categorized as confirmed (meeting both PT INR/PT activity and bilirubin thresholds) or extended (meeting either biochemical criterion alone). We pre-specified a parsimonious Cox model with age (per 10 years) and MELD-Na (per 5 points); the primary outcome was time to all-cause death within 90 days (administrative censoring at day 9

SUBMITTER: Kamezaki H 

PROVIDER: S-EPMC12602991 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature