Social memory deficits and their neural correlates in multiple sclerosis.

ABSTRACT: While the impact of multiple sclerosis (MS) on various cognitive functions has been well documented, social memory - memory of other individuals - remains unexplored. In this study, 26 MS patients and 23 healthy controls underwent task-based fMRI during a social navigation paradigm simulating interpersonal interactions, followed by an episodic social memory recall questionnaire. T1-weighted, T2-FLAIR and diffusion tensor imaging were also acquired. As social navigation metrics have been associated with activity in the precuneus/posterior cingulate cortex (PPCC), we examined this region's functional and volumetric correlates, as well as T2-FLAIR hyperintense white matter lesion burden and microstructural abnormalities in normal-appearing white matter. MS patients showed preserved social nav

SUBMITTER: Magalhaes A 

PROVIDER: S-EPMC12603038 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature