Evidence of diversification and geographic separation in a lineage of <i>Campylobacter jejuni</i> co-circulating in cattle and humans.

ABSTRACT: Campylobacter jejuni, a leading cause of gastroenteritis, is acquired by consuming contaminated food products or via direct contact with animal reservoirs like cattle and poultry. Prior studies have identified specific C. jejuni lineages such as sequence type (ST)-982 and ST-61, to be associated with cattle, while others are linked to chickens and other animal sources. Since cattle-associated lineages were more commonly resistant to tetracycline and detected in patients with a history of cattle contact, we performed comparative genomics on 61 cattle- and 175 human-derived strains collected during an overlapping time period in Michigan. Pangenome analyses and a core-gene phylogeny revealed a high degree of genomic similarity among cattle-associated lineages regardless of strai

SUBMITTER: Rodrigues JA 

PROVIDER: S-EPMC12603118 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature