Exercise increases bone mass by lactate/Gpr81 signaling pathway.

ABSTRACT: Exercise is an effective intervention to promote bone mass by regulating bone homeostasis, but the specific mechanism is ambiguous. Here this study shows that high-intensity interval training (HIIT) was more effective than low-intensity continuous training (LICT) in promoting bone mineral density (BMD). Lactate, a major by-product of HIIT, emerges as a focal point in our investigation of bone homeostasis regulation. In vitro experiments revealed that lactate promotes osteoblast differentiation while inhibiting osteoclast differentiation. However, this effect is markedly suppressed in Gpr81-deficient osteoblasts and osteoclasts. We next found lactate inhibits osteoclast differentiation via the activation of the Gpr81-TAK1-p65 signaling pathway, while promoting osteoblast differentiation thr

SUBMITTER: Guo Y 

PROVIDER: S-EPMC12603139 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature