MZT2B promotes malignant phenotypes in NSCLC cells by enhancing mitochondrial function and COX5B expression.

ABSTRACT: Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, necessitating the identification of novel therapeutic targets. Here, we identify mitotic spindle organizing protein 2B (MZT2B) as a critical oncogenic driver and potential therapeutic vulnerability in NSCLC. TCGA analysis revealed significant MZT2B upregulation in NSCLC tissues, correlating with adverse clinicopathological features and poor prognosis of patients. Single-cell RNA sequencing analysis confirmed predominant MZT2B enrichment within malignant epithelial cells, particularly in proliferating carcinoma subsets, across primary tumors and metastatic sites (brain, lymph node, pleural effusions). Functional enrichment analyses highlighted MZT2B's association with pathways critical for cellular respi

SUBMITTER: Ding X 

PROVIDER: S-EPMC12603160 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature