Impact of four-dimensional computed tomography phase number on target coverage of four-dimensional robustly optimized lung stereotactic body radiotherapy.

ABSTRACT: This study evaluated the dosimetric benefits of various four-dimensional (4D) robust optimization strategies for enhancing plan robustness in free-breathing stereotactic body radiotherapy (SBRT). For ten early-stage lung cancer patients, we generated four helical tomotherapy-SBRT plans (42 Gy/4 fractions) using 4D robust optimization based on 4D-computed tomography (CT) images from all ten phases (4D_10), six phases (4D_6), four phases (4D_4), and two phases (4D_2). Conventional internal target volume (ITV)-based plans served as a reference. Setup uncertainty robustness was assessed across all CT phases. We compared dose and target coverage (D_98%, V_100%) for the gross tumor volume, doses to relevant organs at risk (OARs), and reductions in plan robustness for both nom

SUBMITTER: Yagihashi T 

PROVIDER: S-EPMC12603163 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature