Modeling brain metastases in cost effectiveness analysis of atezolizumab for extensive stage small cell lung cancer.

ABSTRACT: Brain metastases (BM) significantly impact prognosis and healthcare utilization but remain underrepresented in economic evaluations. The IMpower133 trial demonstrated the efficacy of atezolizumab plus chemotherapy (carboplatin and etoposide), particularly among patients without baseline BM, leading to its approval for extensive-stage small-cell lung cancer (EX-SCLC) in several countries. As previous studies did not incorporate BM status, we addressed this gap by including BM in the cost-effectiveness analysis of atezolizumab for EX-SCLC. A four-state Markov model was constructed with the following health states: progression-free, progressive disease (PD) without brain metastases, PD with brain metastases, and death, over a 15-year time horizon. Time-varying efficacy and utility were derive

SUBMITTER: Chen HL 

PROVIDER: S-EPMC12603174 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature