Nasal allergen challenge with dissolved birch tree pollen tablets.

ABSTRACT: The nasal allergen challenge (NAC) is a valuable diagnostic tool for both clinicians and researchers in the field of allergy and its management. In Europe, an aqueous extract Aquagen SQ (ALK-Abelló) was historically the most widely used solution for this purpose. Its production ceased in 2019, creating a gap in available resources. This clinical trial evaluated the feasibility of using dissolved birch pollen tablets, ITULAZAX 12-SQ Bet (ALK-Abelló) tablets as an alternative for NAC. A total of 69 participants with confirmed birch pollen allergy and 20 healthy controls underwent NAC using either dissolved ITULAZAX, dissolved placebo tablets, or a 0.9% saline solution. The primary objective was to assess the sensitivity of NAC with dissolved ITULAZAX. The method demonstrated a sensitivity of

SUBMITTER: Paziou E 

PROVIDER: S-EPMC12603229 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature