Flavonoids interfere with biofilm formation by targeting diguanylate cyclases in multidrug resistant Vibrio cholerae.

ABSTRACT: Rise of antibiotic resistance has led to increased treatment failures in severe cholera cases across the globe. The etiological agent Vibrio cholerae is known for its ability to persist in human gut and environmental settings through biofilm formation. Consequently, the targeting of biofilms is suggested as a viable alternative approach to address the pathogen alongside the rising challenge of drug resistance. Anti-biofilm efficacies of two flavonoids baicalein and fisetin were explored. Minimum biofilm inhibitory concentrations (MBIC) were 40 and 30 µg/mL and minimum biofilm eradication concentrations (MBEC) were 70 and 50 µg/mL for baicalein and fisetin respectively against studied multidrug resistant high biofilm-forming V. cholerae strains. Additionally, both the flavonoids were able t

SUBMITTER: Manna T 

PROVIDER: S-EPMC12603255 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature