Distinct autoreactive CD19^- plasma cell subsets accumulate in lupus-prone mice.

ABSTRACT: Plasma cells (PC) participate in the pathogenesis of systemic lupus erythematosus (SLE) through sustained autoantibody and inflammatory cytokine secretion. Current PC-depleting therapies risk eliminating protective long-lived PCs, highlighting the need to identify pathogenic subsets for selective targeting. Here, using single-cell RNA sequencing, B cell receptor repertoire analysis, and genetic models, we identify disease- and organ-specific PCs in lupus-prone mice. We find a substantial expansion of autoreactive CD19^- PCs, particularly class-switched CXCR3⁺ and phosphatidylcholine-specific B-1-derived subsets, which exhibit unique gene expression profiles. We show that CD19^- PCs originate from CD19⁺ PCs in a unidirectional manner. Peripheral blood from SLE

SUBMITTER: Dang VD 

PROVIDER: S-EPMC12603280 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature