Cancer-specific cytotoxicity of curcumin through regulation of integrin β1 expression in colon cancer.

ABSTRACT: Curcumin has attracted attention for its nontoxic chemopreventive effects; however, the pathways underlying these effects in colon cancer remain unclear. We investigated the potential interplay between curcumin and integrin β1 in colon cancer. Human colon cancer (HCT) 116 cell line and fibroblast cells were treated with curcumin, and cell proliferation was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and western blotting. Using western blotting and confocal microscopy in curcumin-treated HCT116 cells, we analyzed integrin β1 expression and the roles of talin and rab25 in integrin β1 activation by curcumin. Curcumin significantly decreased the survival of HCT116 cells but did not significantly affect the survival of fibroblast cells. Moreover, curcumin s

SUBMITTER: Kim HK 

PROVIDER: S-EPMC12603307 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature