Longitudinal changes in hippocampal morphology before and after temporal lobe epilepsy surgery.

ABSTRACT: Temporal lobe epilepsy (TLE) is associated with progressive neocortical thinning that may be prevented by resective surgery, but little knowledge exists on dynamic changes in the hippocampus. Here, we assessed progressive morphological changes of the hippocampus before and after TLE surgery. In this longitudinal case-control neuroimaging study, we included patients with unilateral drug-resistant TLE before (main cohort n = 23; replication cohort n = 81) or after (n = 54) anterior temporal lobe resection and healthy volunteers (n = 120) matched for age and sex. We compared hippocampal volumes and surface shape morphology on paired scans between groups using linear mixed effects models. We did not find accelerated atrophy of the ipsilateral hippocampus in chronic

SUBMITTER: Velicky Buecheler M 

PROVIDER: S-EPMC12603362 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature