Strategies of neoadjuvant therapy in esophageal cancer: a study on the effects of treatment frequency and surgery interval.

ABSTRACT:

Background

Neoadjuvant immunochemotherapy has shown remarkable efficacy in locally advanced ESCC. Therapy cycles and interval to surgery impact treatment efficacy. However, no consensus exists on the optimal cycles or surgical timing. This study investigates these factors to optimize perioperative management and improve patient outcomes.

Methods

The postoperative follow-up data of 255 patients with esophageal cancer who were treated in the Department of Thoracic Surgery at the Fourth Hospital of Hebei Medical University from between November 6, 2019, and June 4, 2024, were retrospectively analyzed. A multivariate logistic regression with restricted cubic splines (RCS) was employed to model the association between the interval from treatment to surgery and primary outcomes.

SUBMITTER: Lv H 

PROVIDER: S-EPMC12603392 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature