Prognostic Nutritional Index as a Biomarker of Disease Severity and Long-Term Outcome in Guillain-Barre Syndrome.

ABSTRACT:

Background and aims

Guillain-Barré syndrome (GBS) exhibits clinical heterogeneity and variable progression. In low-resource settings, malnutrition and limited treatment worsen prognosis, underscoring the need for a simple prognostic tool. This study evaluated the Prognostic Nutritional Index (PNI) and Nutritional Risk Index (NRI) in relation to GBS severity and long-term outcomes, comparing their predictive value with standard prognostic indicators.

Methods

An observational cohort study of 252 GBS patients enrolled between 2019 and 2024 was conducted. PNI and NRI were calculated using serum albumin, lymphocyte count, and body weight. The GBS-disability score (GBS-DS) assessed baseline severity and 26-week outcomes. Statistical analysis included Chi-square tests, Mann-Whitney

SUBMITTER: Biswas PP 

PROVIDER: S-EPMC12603393 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature