High PD-L1 expression correlates with lymph node metastasis in patients who have undergone radical surgery for primary pulmonary adenocarcinoma.

ABSTRACT:

Background

As the use of immune checkpoint inhibitors in postoperative adjuvant chemotherapy for patients with programmed death-ligand 1 (PD-L1)-expressing lung cancer has been increasing, it is important to accumulate knowledge on PD-L1. In this study, we retrospectively evaluated PD-L1 expression and the related background characteristics in patients who underwent radical surgery for primary pulmonary adenocarcinoma.

Methods

Of 673 non-small cell lung cancer (NSCLC) cases that underwent surgery at Iwate Medical University from January 2017 to December 2022, 453 cases were eligible for study participation. The cases were divided into three groups based on postoperative pathological diagnosis as PD-L1 tumor proportion score (TPS) of less than 1% (negative), 1-49% (low), and

SUBMITTER: Iwai H 

PROVIDER: S-EPMC12603414 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature