16S rRNA sequencing-based analysis of sputum microbiome in patients with acute exacerbations of chronic obstructive pulmonary disease: retrospective cohort study.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is characterized mainly by persistent airflow limitation. Its acute exacerbation of COPD (AECOPD) significantly accelerates the progression of the disease. Current studies have shown that dysregulation of the airway microbiota may be related to the occurrence of AECOPD. However, the dynamic changes of the microbiota in sputum during AECOPD and their correlations with clinical indicators still need to be further clarified. This study aimed to investigate sputum microbiome characteristics and differences between healthy people and patients with AECOPD, and to analyse the correlation between the microecological structural characteristics of the sputum of AECOPD patients and clinical indicators.

Methods

A total of 35 sputum

SUBMITTER: Li S 

PROVIDER: S-EPMC12603422 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature