Construction and identification of a prognostic and therapeutic signature based on ferroptosis-related oxidative stress genes in lung adenocarcinoma.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer-associated deaths globally, with lung adenocarcinoma (LUAD) being the predominant type. Ferroptosis, a unique form of iron-dependent programmed cell death that results from lipid peroxidation, plays a critical role in the initiation and progression of LUAD. In this study, we aimed to construct and identify an effective prognostic model that could serve as a potential therapeutic target for LUAD.

Methods

The expression of ferroptosis-related genes obtained from FerrDb and oxidative stress-related genes collected from MSigDB were analyzed using data from The Cancer Genome Atlas-LUAD cohort. Least absolute shrinkage and selection operator Cox regression, CoxBoost, random survival forest, and stepwise Cox analyses were perfor

SUBMITTER: Yao D 

PROVIDER: S-EPMC12603432 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature