SH3BGRL2 as a vital tumor suppressor and prognostic factor in human esophageal squamous cell carcinoma.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC), a highly aggressive malignancy associated with dismal prognosis, is a global healthcare threat. The molecular mechanisms underlying the carcinogenesis and progression of ESCC remain to be elucidated. This study aims to systematically dissect the pivotal genes and molecular mechanisms that orchestrate the progression of ESCC.

Methods

RNA-sequencing was performed to identify differentially expressed genes between resected ESCC tumor samples and paired adjacent normal tissues. The protein expression levels of SH3 domain binding glutamate rich protein-like 2 (SH3BGRL2) were assessed via immunohistochemistry (IHC) staining in a tissue microarray of 247 cases of ESCC tumor samples and paired normal tissues. Subsequent in vit

SUBMITTER: Chen K 

PROVIDER: S-EPMC12603446 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature