Risk factors for ICU-acquired weakness in patients undergoing mechanical ventilation: a systematic review and meta-analysis.

ABSTRACT:

Background

Intensive care unit (ICU)-acquired weakness (ICU-AW) commonly occurs in mechanical ventilation (MV) patients and is associated with prolonged ventilation, longer ICU stay, and poorer functional outcomes. Evidence regarding the association between corticosteroid (CS) exposure and ICU-AW is inconsistent, and the contribution of other clinical factors is unclear. This study aimed to examine the risk factors connected to the development of ICU-AW related to CS use in patients undergoing MV in the ICU.

Methods

A systematic search in multiple databases, including PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP Database, and the Chinese Biomedical Literature Database (CBM) was conducted up to December 20

SUBMITTER: Zhao M 

PROVIDER: S-EPMC12603452 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature