Bioinformatics and experimental animal model reveal the prognostic value of immunogenic cell death-related proteins in idiopathic pulmonary fibrosis.

ABSTRACT:

Background

Immunogenic cell death (ICD) is a type of regulated cell death (RCD) that activates adaptive immune responses and shapes the immune microenvironment. Its role in idiopathic pulmonary fibrosis (IPF), a progressive and fatal lung disease, remains unclear. This study aims to identify ICD-related gene signatures and evaluate their prognostic value in IPF through bioinformatic analysis and experimental validation.

Methods

Gene expression profiles and clinical data from 176 IPF patients and 20 healthy controls were obtained from the GSE70866 dataset. A set of 34 ICD-related genes was curated from literature. Differential expression analysis, univariate Cox regression, and least absolute shrinkage and selection operator (LASSO)-penalized Cox regression were used to ident

SUBMITTER: Li M 

PROVIDER: S-EPMC12603469 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature