Supplementation of aged garlic extract attenuates age-associated memory impairment and cognitive decline: Involvement of molecular pathways in the cortex and hippocampus.

ABSTRACT: The aging of the human population is associated with increases in comorbidities, including functional impairment and cognitive decline. With decreasing numbers of neurons and declining synaptic plasticity, the aging brain exhibits less perfusion, and thus, is more susceptible to attack by reactive oxygen species (ROS). These changes are associated with increased risks of neurodegenerative diseases, which impact the quality of life. Consequently, there is an urgent need to develop nutraceuticals and holistic approaches that may impede the aging process. Aged garlic extract (AGE) is a nutraceutical that has been shown to display neuroprotective properties; in particular, it has the ability to reduce inflammation, apoptosis and ROS. Given these insights, it is reasonable to hypothesize that A

SUBMITTER: Mony T 

PROVIDER: S-EPMC12603483 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature