Characterization of pleural metastasis in non-small cell carcinomas undergoing intraoperative frozen section examination.

ABSTRACT:

Background

Pleural biopsy via open surgery or video-assisted thoracoscopic surgery is consistently performed in patients with non-small cell lung carcinoma (NSCLC) for diagnostic tumor confirmation, tumor staging, and tumor tissue acquisition. We investigated the clinicopathological characteristics of pleural metastasis in NSCLC, with a specific focus on the comparison between adenocarcinoma (ADC) and squamous cell carcinoma (SqCC). This study aimed to quantify how intraoperative gross finding predicts a positive-for-malignancy (PFM) diagnosis on frozen sections and to delineate histology-specific microscopic features distinguishing ADC from SqCC in PFM cases.

Methods

A retrospective analysis was conducted on 237 pleural biopsies, which underwent intraoperative frozen examin

SUBMITTER: Park JH 

PROVIDER: S-EPMC12603490 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature