SYVN1 aggravates esophageal squamous cell carcinoma development by activating NF-κB pathway to facilitate macrophage M2 polarization.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC) is a leading lethal cancer in the digestive system. Tumor-associated macrophages (TAMs) are key participators in ESCC progression. Mounting evidence has testified the regulatory function of synoviolin (SYVN1) in cancer development. However, the correlation between SYVN1 and TAM polarization remains unclear. As a result, the goal of the present study was to shed light on the new mechanism of SYVN1 in ESCC.

Methods

Collect clinical samples and culture ESCC cell lines to detect SYVN1 expression in ESCC. Construct small interfering RNA targeting SYVN1 and transfect it into ESCC cells to observe its effects on malignant biological processes in cancer cells and macrophage polarization. Use a co-culture system to observe the effe

SUBMITTER: Wang K 

PROVIDER: S-EPMC12603505 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature