Clinical and dosimetric risk factors for radiation pneumonitis after proton therapy in lung cancer patients: a retrospective study.

ABSTRACT:

Background

Given proton therapy's potential to reduce lung dose compared to conventional radiation therapies, this retrospective study aims to identify clinical and dosimetric risk factors associated with the development of radiation pneumonitis (RP) in lung cancer patients treated at our center.

Methods

A retrospective cohort analysis was conducted on lung cancer patients who received proton therapy at the Ion Medicine Center of the First Affiliated Hospital of University of Science and Technology of China from March 2022 to January 2025. Clinical characteristics and dosimetric parameters were collected and analyzed. Univariate and multivariable logistic regression analyses were performed to identify factors associated with the development of grade ≥2 RP.

Results

The

SUBMITTER: Wei N 

PROVIDER: S-EPMC12603518 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature