Tacrolimus overdosing in lung transplant recipients: clinical manifestations and management.

ABSTRACT:

Background

Tacrolimus is essential for preventing rejection after lung transplantation, but its narrow therapeutic index and interindividual variability increase the risk of overdose. Despite the frequency of overdose, the clinical impact of tacrolimus overdose remains poorly defined. This study aimed to systematically assess the frequency, severity, and clinical consequences of tacrolimus overdose in lung transplant recipients and to propose a structured management approach.

Methods

We conducted a retrospective single-center study involving 61 lung transplant recipients treated between January 2022 and December 2023. Tacrolimus overdose was defined as a trough level ≥15 µg/L, and classified as mild (15-<20 µg/L), moderate (20-<25 µg/L), or severe (≥25 µg/L). We analyzed cli

SUBMITTER: Chatzidaki E 

PROVIDER: S-EPMC12603541 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature