Zero-phase-delay synchrony between interacting neural populations: implications for functional connectivity-derived biomarkers.

ABSTRACT: Neural populations synchronise their activity with either zero-phase delay (activity in interacting regions occurs simultaneously) or a phase delay (activity in one region follows the other). In electroencephalography and magnetoencephalography functional connectivity analyses, artefactual connectivity can also occur with zero-phase delay. To minimise artefact, contemporary analyses typically exclude all zero-phase-delay interactions. However, the extent to which "true" interactions are resultingly lost-and the impact this has on the performance of functional connectivity metrics as biomarkers-remains unknown. Here, we show that most cortico-cortical functional connectivity occurs with zero- or near-zero phase delay, even where such connectivity is unlikely to be artefactual. Including, ra

SUBMITTER: Mehra C 

PROVIDER: S-EPMC12603661 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature