Distress and Negative Subtypes of Schizophrenia: Identification, Characterization, and Neurostructural Profiles.

ABSTRACT:

Background

Heterogeneity in schizophrenia spectrum disorders is a major challenge to implementing personalized medicine and uncovering etiological pathways. Recent work identified subtypes of schizophrenia that exhibit unique patterns of clinical symptoms and features using a common clinical scale. The current study sought to: (1) replicate prior identification of subtypes using the Positive and Negative Syndrome Scale (PANSS) in a new cohort of people with schizophrenia; (2) further characterize differences between subtypes in symptoms, affect, cognition, functioning, and personality; and (3) determine if brain structure abnormalities vary across subtypes.

Study design

Phenotypic data were obtained on 356 individuals with schizophrenia spectrum disorders. Structural brain m

SUBMITTER: Feola B 

PROVIDER: S-EPMC12603685 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature