Intravascular haemolysis following pulsed field ablation pulmonary vein isolation for atrial fibrillation: a systematic review.

ABSTRACT:

Background

Pulsed field ablation (PFA) has emerged as a promising non-thermal alternative to conventional atrial fibrillation (AF) ablation techniques. However, intravascular haemolysis has been increasingly recognised as a potential complication, with variable incidence and clinical significance.

Objective

To systematically review the available clinical evidence on PFA-related haemolysis, focusing on biochemical markers, clinical manifestations and device-specific differences.

Methods

PubMed, Embase and Cochrane databases were searched until 20 May 2025 for clinical studies evaluating primarily PFA-pulmonary vein isolation for AF that reported haemolysis, acute kidney injury (AKI) or relevant biomarker changes. The primary outcome was evaluation of incidence and bioc

SUBMITTER: Koh TWY 

PROVIDER: S-EPMC12603721 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature