Language dysfunction and related amyloid-β in Alzheimer's disease mediated by brain functional connectivity changes.

ABSTRACT:

Background

Language dysfunction occurs early in Alzheimer's disease (AD) and whether amyloid-β pathology is related to language dysfunction remains unclear. Functional connectivity (FC) in language networks is critical for language function. We hypothesize that altered FCs in fronto-temporal regions (core language areas) mediate the association between amyloid-β burden and language impairment.

Methods

A total of 110 individuals were recruited including 44 cognitively unimpaired individuals, 24 mild cognitive impairment patients and 42 AD patients. The acoustic features and semantic content were extracted from speech recordings of cookie-theft picture description for language assessment. Resting-state functional magnetic resonance imaging and 18F-florbetapir positron emission

SUBMITTER: Xiao JW 

PROVIDER: S-EPMC12603769 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature