Repetitive transcranial magnetic stimulation-driven modulation of unbiased functional connectivity in the supracallosal anterior cingulate cortex causally ameliorates information processing speed in amnestic mild cognitive impairment.

ABSTRACT:

Introduction

Amnestic mild cognitive impairment (aMCI) exhibits biased functional connectivity (FC) abnormalities impairing neural plasticity modulation. This study aimed to identify unbiased FC deficits using a brain-wide association study (BWAS) and investigate repetitive transcranial magnetic stimulation (rTMS)-driven plasticity restoration.

Methods

BWAS identified unbiased FC-altered voxels (robustness-validated). Region-of-interest (ROI)-wise FC analysis localized disrupted circuits, which were modulated through precuneus-targeted rTMS. Effective connectivity (EC) tested whether the precuneus exerted a causal influence on these disrupted circuits. Correlation analyses linked FC plasticity to cognitive and clinical outcomes.

Results

Eleven brain regions with 31 al

SUBMITTER: Chen J 

PROVIDER: S-EPMC12603778 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature