Association between early age at menarche and overactive bladder risk in women: insights from NHANES and Mendelian randomization analysis.

ABSTRACT:

Background

Early age at menarche (AAM) has been linked to adverse metabolic trajectories that may influence bladder function, but the association between AAM and overactive bladder (OAB), and the mediating role of body mass index (BMI), remains unclear. This study aimed to examine the association of AAM with OAB risk, quantify BMI mediation, and evaluate causality using Mendelian randomization (MR).

Methods

We analyzed data from 9,647 women in the National Health and Nutrition Examination Survey (NHANES, 2011-2018). OAB was defined by an Overactive Bladder Symptom Score (OABSS) ≥3. Multivariable logistic regression and restricted cubic spline (RCS) analyses evaluated the AAM-OAB relationship, adjusting for demographic, clinical, and lifestyle confounders. Mediation analysis

SUBMITTER: Huang G 

PROVIDER: S-EPMC12603819 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature