Myeloperoxidase inhibits prostate cancer progression, suppresses the PI3K/AKT signaling pathway and reshapes the immune microenvironment.

ABSTRACT:

Background

The progression of prostate cancer (PCa) is closely associated with metabolic reprogramming and immune microenvironment dysregulation, while the mechanisms by which lactate-associated genes (LAGs) play a role remain unclear. This study aimed to elucidate the prognostic value and functional role of myeloperoxidase (MPO) in PCa and to explore its potential as a therapeutic target through comprehensive bioinformatics and experimental analyses.

Methods

We integrated The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases to identify differentially expressed LAGs. Experimental validation using PCa tissues, PCa cell lines, and xenograft models assessed the functional role of MPO. Immune microenvironment analysis evaluated immune cell infiltration and

SUBMITTER: Zhou M 

PROVIDER: S-EPMC12603842 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature