Prophylactic adjuvant therapy for postoperative recurrence of urethral stricture: a narrative review.

ABSTRACT:

Background and objective

Urethral stenosis is a prevalent urological disorder characterized by the fibrotic narrowing of the urethral lumen, leading to symptoms of lower urinary tract obstruction and significantly impacting patients' quality of life. Despite substantial advancements in surgical interventions, postoperative recurrence continues to pose a significant clinical challenge. In recent years, adjunctive pharmacologic therapies aimed at reducing fibrosis and preventing restenosis have garnered increasing attention. This narrative review summarizes the current evidence on postoperative pharmacological adjuvant therapies and emerging drug-delivery systems designed to reduce recurrence following urethral stricture surgery.

Methods

For the period from 2004 to 2025, we se

SUBMITTER: Chen H 

PROVIDER: S-EPMC12603851 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature