Paternal Valproate Use and Neurodevelopmental Disorder and Congenital Malformation Risk in Offspring.

ABSTRACT:

Importance

Limited clinical evidence is available about the risk of neurodevelopmental disorders (NDD), including autism spectrum disorders and congenital malformations (CM), in offspring following paternal exposure to antiseizure medications.

Objective

To investigate the risk of NDD (any subtype) and CM (major and/or minor) in offspring paternally exposed to valproate vs lamotrigine or levetiracetam monotherapy within 3 months prior to conception.

Design, setting, and participants

This observational, population-based, nationwide cohort study used Nordic registries data with family linkage (offspring born between 1997-2018 [Denmark], 2010-2019 [Norway], and 2007-2019 [Sweden]). Offspring born within the study period and paternally exposed to either (1) valproate or (2

SUBMITTER: Colas S 

PROVIDER: S-EPMC12603866 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature