Association between tacrolimus intrapatient variability and clinical outcomes in kidney transplantation: a retrospective cohort study.

ABSTRACT:

Background

In therapeutic drug monitoring (TDM) of tacrolimus, trough concentration is the most commonly used monitoring indicator, which has limited association with clinical outcomes. Intrapatient variability (IPV), as a novel monitoring marker for describing the extent of fluctuation in blood concentration, holds promise as an additional monitoring tool. The effect of tacrolimus IPV on Chinese kidney transplantation outcomes is unclear, and the aim of this study is to explore the association between IPV and poorer outcomes of Chinese kidney transplantation recipients and to discuss the influence of genotype.

Methods

A total of 152 patients were enrolled, whose kidney transplantation operations were carried out from January 2015 to February 2022 in Peking University Third

SUBMITTER: Chen H 

PROVIDER: S-EPMC12603870 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature