Evaluation of Interventions for Cognitive Symptoms in Long COVID: A Randomized Clinical Trial.

ABSTRACT:

Importance

Treatment for cognitive dysfunction due to postacute sequelae of long COVID (ie, symptoms of fatigue, malaise, weakness, confusion that persist beyond 12 weeks after an initial COVID infection) remains a significant unmet need.

Objective

To test evidence-based rehabilitation strategies for improving cognitive symptoms in persons with long COVID.

Design, setting, and participants

This was a 5-arm, multicenter, randomized clinical trial of 3 remotely delivered interventions conducted between August 17, 2023, and June 10, 2024. The study took place at 22 trial sites and included the screening of individuals with cognitive long COVID.

Interventions

Participants were randomized to 1 of 5 arms: adaptive computerized cognitive training (BrainHQ [Posit Scien

SUBMITTER: Knopman DS 

PROVIDER: S-EPMC12603944 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature