A Lipidomic Exploration of the Effects of High-Intensity Interval Exercise in Healthy Men after Metformin Intake.

ABSTRACT: We have previously found that high-intensity interval exercise (HIIE) affected metformin pharmacokinetics compared with rest. In this scenario, changes in individual lipids could play an important role. The prolonged responses of the lipidome to HIIE have not been explored. This study aimed to explore differences in the plasma lipidomic profiles between HIIE and rest, both under metformin treatment. Nine healthy males participated in two sessions where they received 1,000 mg of metformin. In session A, they performed HIIE at an average intensity of 67% of the maximum heart rate for a total duration of 76 min, whereas in session B, they rested. Plasma was collected before taking metformin and during each session (in total, 14 time points spanning 12 h). Samples were analyzed through lipidom

SUBMITTER: Neuhaus R 

PROVIDER: S-EPMC12604030 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature