Transient π-coordination enables nucleophilic borylation of simple arenes.

ABSTRACT: Borylation of an arene typically proceeds via transition-metal-catalyzed C-H activation. We report here that transient π-coordination to chromium activates 1 equiv. of a simple arene towards nucleophilic borylation with B₂(pin)₂ in the presence of an additive such as K₂CO₃ or KF. The transient activation of the substrate is achieved via in situ ligand exchange with a naphthalene chromium complex, followed by borylation of the resulting arene chromium complex. Electron-rich and sterically hindered arenes, challenging substrates for transition-metal-catalyzed C-H borylation, react well under these conditions. Mechanistic studies support an anionic mechanism, where a borate species undergoes nucleophilic addition to the arene chromium

SUBMITTER: Mutoh Y 

PROVIDER: S-EPMC12604050 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature