<i>In Silico</i> Target Discovery of Kaempferol: Therapeutic Effect of Kaempferol on Atopic Dermatitis through Regulation of Aryl Hydrocarbon Receptor.

ABSTRACT: The aryl hydrocarbon receptor (AhR) is known to bind several exogenous ligands such as natural plant flavonoids, synthetic polycyclic aromatic hydrocarbons, and dioxin-like compounds, but its association with kaempferol (KF) is unknown. Therefore, in this study, AhR was explored as an atopic dermatitis (AD)-regulating target of KF for AD regulation using in silico prediction, and pharmacological prediction and various AD-induced models confirmed that KF exhibited pharmacological activity through AhR regulation. Also, the results of the study showed that KF regulated epidermal differentiation terminal proteins through the AhR pathway in HaCaT cells stimulated with TNF-α/IFN-γ, and the therapeutic effect of KF was also proven in an AD-induced mouse model and a reconstructed human skin

SUBMITTER: Kim EN 

PROVIDER: S-EPMC12604056 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature