A new hybrid echocardiography and arterial pressure waveform approach for non-invasive reconstruction of the entire left ventricular pressure waveform.

ABSTRACT:

Aims

Non-invasive estimation of left ventricular pressure (LVP) is crucial for managing cardiovascular diseases such as heart failure and myocardial infarction (MI). Current clinical practices rely on invasive catheterization, limiting its feasibility for routine or longitudinal monitoring. This study evaluates the accuracy of a novel LVP reconstruction algorithm in preclinical (rat) experiments.

Methods and results

Using a standard coronary occlusion/reperfusion model (n = 39 rats), we validated our algorithm across three physiological states: baseline, myocardial ischaemia, and MI. LVP waveforms were reconstructed using only carotid pressure waveforms and echocardiographic measurements. Algorithm performance was assessed by comparing reconstructed LVP waveforms to i

SUBMITTER: Bilgi C 

PROVIDER: S-EPMC12604097 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature