Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration.

ABSTRACT: Implant-associated complications-including infection, adverse immune responses, and poor tissue integration-pose significant risks to patients, often leading to implant failure, revision surgeries, or chronic disease. Current chemical-based strategies, such as antibiotic or drug-releasing systems, are limited by short-term efficacy, narrow therapeutic windows, and potential toxicity. Surface topography offers a promising alternative, but most designs target single cell types and overlook the complex, multicellular dynamics at the implant-host interface. Here, a new multifunctional platform is introduced based on nano-micro hybrid wrinkled topographies fabricated via a custom nanofabrication method that combines layer-by-layer (LbL) self-assembly with mechanical nanomanufacturing. This syst

SUBMITTER: Asadi Tokmedash M 

PROVIDER: S-EPMC12604099 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature