Serum inflammatory markers for the screening and diagnosis of periprosthetic joint infection: a systematic review and meta-analysis.

ABSTRACT: Aim: As part of a multi-society effort to derive a unified consensus definition of periprosthetic joint infection (PJI), a systematic review of serum inflammatory marker diagnostic performance for hip, knee, and shoulder PJI was performed. Methods: PubMed (MEDLINE) and EMBASE were searched for studies reporting the diagnostic performance of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell count (WBC), fibrinogen, interleukin-6 (IL-6), or D-dimer for PJI. From these, each markers' pooled sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), and area under the summary receiver operating characteristic curve (AUSROC) were calculated using a random-effects model. Results: A total of 89 studies reporte

SUBMITTER: Sigmund IK 

PROVIDER: S-EPMC12604141 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature