Theta Burst Stimulation as a tool to decrease drinking in treatment-seeking alcohol users: study protocol for a randomized, double-blind, sham-controlled clinical trial.

ABSTRACT:

Background

Alcohol use disorder (AUD) remains a prevalent and challenging condition, with current behavioral and pharmaceutical treatments yielding limited success and high relapse rates. Non-invasive neuromodulation techniques, such as transcranial magnetic stimulation (TMS), offer promising therapeutic alternatives. TMS has demonstrated efficacy in modulating brain circuits associated with the limbic system and cognitive control, both critical in AUD pathology. While the dorsolateral prefrontal cortex (DLPFC) and medial prefrontal cortex (MPFC) have been identified as potential TMS targets, no studies have evaluated both sites against a sham condition in a single trial. This randomized, double-blind, sham-controlled clinical trial addresses this gap by evaluating the efficacy of

SUBMITTER: Kinney KR 

PROVIDER: S-EPMC12604150 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature