Neuroimaging epicenters and the related neurobiological signatures in patients with postherpetic neuralgia.

ABSTRACT:

Background

Postherpetic neuralgia (PHN) is a typical neuropathic pain syndrome and frequently involves central and peripheral neuropathic signs. Considering the long-term pain conditions, pain, sleep disturbance, and mental disorders often create a self-perpetuating vicious cycle, wherein each factor exacerbates the others. The current understanding of the complex pathology of PHN remains limited, which hinders the clinical treatment of its pain symptoms.

Methods

To explore the neurobiological alterations linked with PHN, we utilized a novel method, the neuroimaging epicenter, to identify the candidate sites of its pathological processes and further investigated the related neurobiological signatures by exploring the associations of gene expression, neurotransmitter receptor

SUBMITTER: Li Q 

PROVIDER: S-EPMC12604156 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature