Cognitive and intellectual functioning in leukodystrophy patients: a systematic review.

ABSTRACT:

Background

'Leukodystrophies' encompass a group of genetic disorders affecting brain white matter, mostly characterized by neurological deterioration. Manifestations include mood changes, cognitive decline, motor dysfunction, and often early death. Underestimation of the cognitive decline may result in a lack of suitable interventions and adequate guidance. This systematic review aims to gain insight into available information on the cognitive and intellectual profile of leukodystrophy patients, providing a basis for further research.

Methods

MEDLINE, EMBASE and PsychINFO were searched for studies examining processing speed, attention, memory, language, social cognition, visuospatial functioning and construction, and intelligence in patients with any type of confirmed leukod

SUBMITTER: Grol WHM 

PROVIDER: S-EPMC12604172 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature