PRC1, CDCA3, and CDC20 are upregulated and Treg numbers are decreased in canine massive hepatocellular carcinoma.

ABSTRACT:

Background

The mechanisms underlying the development and prognosis of hepatocellular carcinoma (HCC) differ between dogs and humans. Although genetic alterations can cause carcinogenesis, the genetic alterations in canine HCC may differ from those observed in human HCC. In humans, various signaling pathways, oncogenes, and tumor suppressor genes are associated with HCC oncogenesis. Immune cells have been reported to be associated with prognosis. In canine HCC, the genes related to oncogenesis and prognosis remain unclear. Therefore, in this study, we used RNA sequencing to comprehensively evaluate abnormally expressed genes and infer immune cell composition in canine HCC.

Results

Fourteen dogs histopathologically diagnosed with HCC and four dogs with normal livers (NL) were

SUBMITTER: Tanaka T 

PROVIDER: S-EPMC12604188 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature