Transcriptomic landscape of pseudorabies virus-induced encephalitis reveals key lncRNAs involved in host-neurotropic virus interactions.

ABSTRACT: Pseudorabies virus (PRV) infection causes fatal encephalitis across various species, a condition known as pseudorabies encephalitis (PRE). However, the molecular mechanisms underlying PRE remain poorly understood. Long noncoding RNAs (lncRNAs) have emerged as important regulators of gene expression in neurological diseases and viral infections. This study explores genome-wide transcriptional alterations in a mouse model of PRV-induced encephalitis. The intranasal inoculation of mice with PRV induced severe encephalitis, characterized by high viral loads, significant inflammatory responses, and the onset of neurological symptoms. RNA-seq analysis revealed 683 differentially expressed (DE) mRNAs and 179 DElncRNAs in PRV-infected brains compared with controls. Functional and pathway analyses

SUBMITTER: Phan Van T 

PROVIDER: S-EPMC12604289 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature